Frequency, characteristics and risk assessment of pulmonary arterial hypertension with a left heart disease phenotype.

ABSTRACT:

Aim

To obtain real-world evidence about the features and risk stratification of pulmonary arterial hypertension (PAH) with a left heart disease (LHD) phenotype (PAH-LHD).

Methods and results

By reviewing the records of consecutive incident PAH patients at 7 tertiary centers from 2001 to 2021, we selected 286 subjects with all parameters needed to determine risk of death at baseline and at first follow-up with COMPERA and COMPERA 2.0 scores. Fifty seven (20%) had PAH-LHD according to the AMBITION definition. Compared with no-LHD ones, they were older, had higher BMI, more cardiovascular comorbidities, higher E/e' ratio and left atrial area, but lower BNP concentrations and better right ventricular function and pulmonary hemodynamics. Survival was comparable between PAH-LHD an

SUBMITTER: Toma M 

PROVIDER: S-EPMC11839797 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature