The role of FTO in m6A RNA methylation and immune regulation in Staphylococcus aureus infection-related osteomyelitis.

ABSTRACT:

Background

Regulators of n6-methyladenosine (m6A) RNA modification play important roles in many diseases; however, their involvement in Staphylococcus aureus (S. aureus)-related osteomyelitis remains inadequately explored. Therefore, this study aims to investigate the role of m6A in S. aureus infection-related osteomyelitis and elucidate its underlying mechanisms.

Methods

We downloaded the S. aureus infection-related osteomyelitis infection dataset GSE30119 from the Gene Expression Omnibus database. Initially, we constructed a diagnostic model based on m6A genes and predicted the hub node miRNAs and transcription factors by constructing a protein-protein interaction network. Subsequently, a prognostic model was built using LASSO regression, the re

SUBMITTER: Liu S 

PROVIDER: S-EPMC11839825 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature