Integrative analysis of lncRNAs in rheumatoid arthritis: from bioinformatics to experimental validation.

ABSTRACT: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive joint damage and systemic inflammation. Despite advances in treatment, challenges persist in early diagnosis and personalized therapy. Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators in immune pathways and inflammation, offering potential as diagnostic biomarkers and therapeutic targets. Using GEO datasets (GSE169082, GSE124373), we identified differentially expressed genes in peripheral blood mononuclear cells of RA patients. Functional enrichment and pathway analyses were conducted to elucidate their roles. Key lncRNAs (LINC00963, SNHG15, SNHG3) were experimentally validated via real-time PCR in patient samples. Protein-protein interaction networks and ceRNA networks were constructed

SUBMITTER: Golestanifar A 

PROVIDER: S-EPMC11839865 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature