Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality among hypertension patients.

ABSTRACT: The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) reflects the balance between pro- and anti-atherogenic lipoproteins. This study aims to explore the relationship between NHHR and mortality among hypertension patients. Data from 17,075 hypertensive adults in the National Health and Nutrition Examination Survey (NHANES) were analyzed. Multivariate Cox regression and restricted cubic splines were used to assess the correlation between NHHR and mortality. A segmented Cox model evaluated threshold effects, and sensitivity analyses confirmed result robustness. Machine learning algorithms were used to establish a prediction model. Over a median follow-up of 84 months, 3625 deaths occurred. A U-shaped association was observed between NHHR and both a

SUBMITTER: Su X 

PROVIDER: S-EPMC11839901 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature