Development of a flexible 3D printed TPU-PVC microfluidic devices for organ-on-a-chip applications.

ABSTRACT: The development of cost-effective, flexible, and scalable microfluidic devices is crucial for advancing organ-on-a-chip (OoC) technology for drug discovery and disease modeling applications. In this study, we present a novel 3D-printed flexible microfluidic device (3D-FlexTPU-MFD) fabricated through a one-step fused deposition modeling (FDM) process using thermoplastic polyurethane (TPU) as the printing filament and polyvinyl chloride (PVC) as the bonding substrate. The device's compatibility was evaluated with various cell types, including human primary myoblasts, human primary endothelial cells (HUVEC), and human iPSC-derived optic vesicle (OV) organoids. Myoblasts cultured within the device exhibited high viability, successful differentiation, and the formation of aligned myotube bundle

SUBMITTER: Kado Abdalkader R 

PROVIDER: S-EPMC11839916 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature