Fecal microbiota and genetics in pediatric-onset orofacial granulomatosis and Crohn´s disease.

ABSTRACT: Orofacial granulomatosis (OFG) is a rare chronic inflammatory condition. It is under debate, whether it is a condition of its own or merely a subtype of Crohn's disease (CD). We aimed to search for markers characteristic of patients with pediatric-onset OFG compared to patients with pediatric-onset CD. We recruited young patients with OFG (with or without CD, n = 29), CD (n = 24), and healthy controls (n = 20). All participants provided a fecal sample for microbiota and calprotectin analyses and saliva for DNA analysis of genes associated with OFG and kept a 3-day food diary. Oral disease activity was evaluated using The Oral Disease Activity Score by an otorhinolaryngologist and a dentist. We observed decreased relative abundance in class Clostridia and increased relative abundances of cl

SUBMITTER: Hoyhtya M 

PROVIDER: S-EPMC11839994 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature