Product and trial design considerations on the path towards a vaccine to combat opioid overdose.

ABSTRACT: Opioid overdose deaths are an evolving public health emergency in the United States. Recent advancements in drug conjugate vaccine design and adjuvantation technologies have re-ignited interest in the potential clinical utility of opioid vaccination. Here we present the concept of fentanyl vaccination as a complementary strategy for opioid overdose prevention with a focus on vaccine safety, efficacy, and considerations for vaccine development and testing in early phase human clinical trials.

SUBMITTER: Angelidou A 

PROVIDER: S-EPMC11840009 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature