Glymphatic dysfunction exacerbates cognitive decline by triggering cortical degeneration in Parkinson's disease: evidence from diffusion-tensor MRI.

ABSTRACT: The glymphatic system may play a central role in cognitive impairment associated with Parkinson's disease, but its relationship with regional cortical atrophy is not fully explored. To explore associations among glymphatic dysfunction, regional cortical degeneration and cognitive impairment in Parkinson's disease participants, we evaluated 51 participants with documented Parkinson's disease (28 men; age, 61.65 ± 8.27 years) and 30 age- and sex-matched normal controls (11 men; age, 59.2 ± 5.90 years) who underwent 3.0-T MRI of the brain, including high-resolution T1-weighted imaging and diffusion-tensor imaging along the perivascular space as a surrogate for glymphatic flow. Cortical grey matter volume was segmented automatically based on three-dimensional T1-weighted sequences. Cognitive f

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11840164 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature