Diffuse nuclear Overhauser effect MRI contrast changes detected in multiple sclerosis subjects at 7T.

ABSTRACT: Multiple sclerosis is an inflammatory demyelinating condition of the central nervous system affecting approximately 1 million people in the USA. Although standard structural MRI techniques are now the main imaging modality for multiple sclerosis diagnosis and management, they are yet to provide information regarding the metabolic profile of the disease. Ultra-high field 7T MRI systems have provided gains in signal-to-noise ratio (SNR) and spatial resolution for structural MRI as well as larger chemical shifts leading to improvements in specialized imaging sequences, such as nuclear Overhauser effect (NOE) imaging, that can evaluate macromolecular metabolite composition. In this work, NOE images were acquired on a cohort of multiple sclerosis and healthy control subjects to spatially map di

SUBMITTER: Jacobs PS 

PROVIDER: S-EPMC11840165 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature