Phenotypic and genetic heterogeneity of <i>Acinetobacter baumannii</i> in the course of an animal chronic infection.

ABSTRACT: Acinetobacter baumannii is a nosocomial pathogen associated with various infections, including urinary tract infections (UTIs). In the course of an infection, A. baumannii is known to rapidly become resistant to antibiotic therapy, but much less is known about possible adaptation without antibiotic pressure. Through a retrospective study, we investigated within-host genetic diversity during a subclinical 5-year UTI in an animal-patient after withdrawal of colistin treatment. We conducted whole-genome sequencing and phenotypic assays on 17 clonally related isolates from the Sequence Type 25 lineage. Phylogenomic analysis revealed their proximity with animal and human strains from the same country suggesting zoonotic transmission (France). In this case study, the clonally relat

SUBMITTER: Bednarczuk L 

PROVIDER: S-EPMC11840173 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature