Spot Versus 24-Hour Urine Osmolality Measurement in Autosomal Dominant Polycystic Kidney Disease: A Diagnostic Test Study.

ABSTRACT:

Rationale & objective

Arginine vasopressin (AVP) is an established driver of cyst growth in autosomal dominant polycystic kidney disease (ADPKD). Urine osmolality (osm) measures are surrogate markers of AVP activity. Both 24-hour and spot urine samples are used as indicators of AVP suppression. The agreement between these 2 measurements remains unclear.

Study design

A retrospective cohort study.

Setting & study population

Three hundred and forty-nine patients with ADPKD with 839 urine samples from a tertiary care center.

Selection criteria for study

Patients with ADPKD with records of spot and 24-hour urine measurements.

Data extraction

Consecutive patients' data from January 2018 to March 2023 were extracted from the quality assurance database of The Ot

SUBMITTER: Akbari A 

PROVIDER: S-EPMC11840182 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature