A pan-cancer analysis of homeobox family: expression characteristics and latent significance in prognosis and immune microenvironment.

ABSTRACT:

Background

The Homeobox (HOX) gene family are conserved transcription factors that are essential for embryonic development, oncogenesis, and cancer suppression in biological beings. Abnormally expressed HOX genes in cancers are directly associated with prognosis.

Methods

Public databases such as TCGA and the R language were used to perform pan-cancer analyses of the HOX family in terms of expression, prognosis, and immune microenvironment. The HOX score was defined, and potential target compounds in cancers were predicted by Connective Map. Immunohistochemistry was employed to validate protein expression levels. Gene knockdowns were used to verify the effects of HOXB7 and HOXC6 on the proliferation and migration of lung adenocarcinoma (LUAD) cells.

Results

HOX genes p

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11840236 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature