The relationship between SV2A levels, neural activity, and cognitive function in healthy humans: A [11C]UCB-J PET and fMRI study.

ABSTRACT: Synaptic terminal density is thought to influence cognitive function and neural activity, yet its role in cognition has not been explored in healthy humans. We examined these relationships using [11C]UCB-J positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) in 25 healthy adults performing cognitive function tasks in the scanner. We found a significant positive association between synaptic terminal density, indicated by [11C]UCB-J PET distribution volume ratio (DVRcs), and neural activity during task switching (PLS-CA, second canonical component, r = 0.63, p = 0.043) with the thalamus-putamen data positively contributing to this relationship (PLS-CA loading 0.679, exploratory Pearson's correlation r = 0.42, p = 0.044, uncorrected).

SUBMITTER: Shatalina E 

PROVIDER: S-EPMC11840333 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature