<i>Staphylococcus aureus</i>-specific TIGIT⁺ Treg are present in the blood of healthy subjects - a hurdle for vaccination?

ABSTRACT: Staphylococcus aureus poses an enormous burden of morbidity and mortality worldwide. Making an efficacious vaccine has however proven extremely challenging. Due to colonizing interactions, pre-existing S. aureus-specific CD4⁺ T cells are often found in the human population and yet a detailed characterization of their phenotypes and how they might in turn impact vaccine efficacy are thus far unknown. Using an activation induced marker assay to sort for S. aureus-specific CD4⁺ T cells in an effector function-independent manner, single cell transcriptomic analysis was conducted. Remarkably, S. aureus-specific CD4⁺ T cells consisted not only of a broader spectrum of conventional T cells (Tcon) than previously described but also of re

SUBMITTER: Clegg J 

PROVIDER: S-EPMC11840346 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature