Causal effect of fasting serum glucose on atherosclerotic cardiovascular disease: a multivariable Mendelian randomization.

ABSTRACT:

Objectives

Observational studies have reported that diabetes is a risk factor that increases the risk of atherosclerotic cardiovascular disease (ASCVD). However, the causal relationship remains a matter of debate. This study aimed to analyze the relationship between fasting serum glucose (FSG) and ASCVD.

Methods

This study used data from the Korean Cancer Prevention Study-II (KCPS-II) Biobank, consisting of 159,844 people recruited with consent from 18 health examination centers from 2004 to 2013. Outcomes were confirmed based on diagnoses on hospital discharge summaries from National Health Insurance System. We used linear and non-linear Mendelian randomization (MR) methods. The outcome data were obtained from KCPS-II, and the exposure data were derived from the Korean Geno

SUBMITTER: Lee SH 

PROVIDER: S-EPMC11840400 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature