CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis.

ABSTRACT:

Background & aims

Liver cancer is a significant global health issue, with its incidence rising in parallel with the obesity epidemic. The limited therapeutic options available emphasize the need for a better understanding of the molecular pathways involved in its pathogenesis. While much of the previous research has focused on transcriptional changes, this study examines translational alterations, specifically the role of cytoplasmic polyadenylation element binding protein 4 (CPEB4), a key regulator of translation.

Methods

We analyzed publicly available patient databases and conducted studies using human and mouse liver cancer cells, xenograft and allograft models, mouse models of high-fat diet-related liver cancer, and CPEB4 knockout and knockdown mice and cell lines.

Re

SUBMITTER: Delgado ME 

PROVIDER: S-EPMC11840500 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature