Melanoma Tumor Mutational Burden and Indoor Tanning Exposure.

ABSTRACT:

Importance

UV-induced mutagenesis leads to a higher tumor mutational burden (TMB) in cutaneous melanoma relative to other cancer types. TMB is an important prognostic marker in advanced melanoma; higher TMB is associated with greater clinical response to immune checkpoint inhibition and improved survival.

Objective

To evaluate the association between cutaneous melanoma TMB and indoor tanning exposure, as well as other demographic, dermatologic, and tumor characteristics.

Design, setting, and participants

This retrospective cohort study took place at Dana-Farber Cancer Institute, a tertiary-care cancer treatment center in Boston, Massachusetts, between 2013 and 2022. Patients with a diagnosis of cutaneous melanoma for whom next-generation sequencing data and tanning be

SUBMITTER: Hanrahan GB 

PROVIDER: S-EPMC11840639 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature