Sex-Specific Association of Myocardial Fibrosis With Mortality in Patients With Aortic Stenosis.

ABSTRACT:

Importance

Myocardial fibrosis in aortic stenosis (AS) may exhibit sex differences. However, its prognostic significance in women with AS remains unclear.

Objective

To investigate sex differences in myocardial fibrosis assessed by cardiovascular magnetic resonance (CMR) and evaluate its prognostic value in women and men with AS.

Design, setting, and participants

Patients with severe AS who underwent CMR before aortic valve replacement (AVR) were prospectively enrolled from 13 international sites between March 2011 and September 2021. Myocardial fibrosis was evaluated using extracellular volume fraction (ECV%) and late gadolinium enhancement (LGE). The main analysis was conducted on patients without obstructive coronary artery disease (CAD), defined as those with no hi

SUBMITTER: Kwak S 

PROVIDER: S-EPMC11840686 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature