Early vs Delayed Bypass Surgery in Patients With Acute Coronary Syndrome Receiving Ticagrelor: The RAPID CABG Randomized Open-Label Noninferiority Trial.

ABSTRACT:

Importance

Perioperative bleeding is a major concern in patients receiving ticagrelor for acute coronary syndromes (ACS) when coronary artery bypass graft (CABG) surgery is required.

Objective

To evaluate whether early CABG surgery at 2 to 3 days after ticagrelor cessation is noninferior to waiting 5 to 7 days.

Design, setting, and participants

RAPID CABG was a noninferiority, open-label randomized trial with 6 months of follow-up. Participants were patients with ACS who had received ticagrelor and required CABG. Patients were enrolled in tertiary centers in Canada between January 2016 and March 2021. Data were analyzed from March 2021 to December 2023.

Intervention

Early or delayed CABG.

Main outcomes and measures

The primary outcome was based on noninf

SUBMITTER: So DYF 

PROVIDER: S-EPMC11840690 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature