Surgical Management of Thick Primary Cutaneous Melanoma in the US.

ABSTRACT:

Background

There remains significant variability in the surgical management of thick melanoma patients with clinically node-negative disease. We evaluated factors influencing overall survival (OS) in these patients, focusing on the surgical management of the primary tumor and nodal basin.

Methods

Using the National Cancer Database, we identified 7647 patients diagnosed between 2012 and 2017 with thick melanoma (> 4 mm, T4) and clinically node-negative disease. 4332 patients had complete data and met all inclusion criteria. These patients were stratified into three groups based on nodal assessment: sentinel lymph node biopsy (SLNB), elective lymphadenectomy (ELND), or no nodal evaluation (NNE). OS was compared using Kaplan-Meier analyses and multivariable Cox proportional haz

SUBMITTER: Cowman AW 

PROVIDER: S-EPMC11840694 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature