Implementing a tridimensional diagnostic framework for personalized medicine in neurodegenerative diseases.

ABSTRACT: Neurodegenerative diseases (NDDs) pose a significant challenge in modern medicine due to their clinical heterogeneity, multifactorial etiologies, and frequent co-pathologies. Traditional diagnostic systems, based on clinical symptoms and post mortem findings, are limited in capturing the complex interactions among genetic, molecular, and neuroanatomical factors. This manuscript introduces a novel tridimensional diagnostic framework that integrates these factors across three key axes: etiology (genetic and environmental influences), molecular markers (primary and secondary biomarkers), and neuroanatomoclinical correlations. Through case studies, we demonstrate the framework's ability to synthesize incomplete datasets, stratify patients, and guide precision medicine. By incorporating omics t

SUBMITTER: Menendez-Gonzalez M 

PROVIDER: S-EPMC11840702 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature