Ultrasmall radical metal organic cage as cascade antioxidant nanozyme for renal injury.

ABSTRACT: Rationale: As substitutes for natural enzymes, nanozymes offer tunable enzyme-like activities and remarkable structural stability, granting them the potential to treat various diseases, including renal ischemia-reperfusion (I/R) injury. However, the majority of developed nanozymes suffer from unclear structures and limited activity profiles, which hinder the study of their structure-activity relationships, catalytic diversity, mass production, and clinical application. Methods: Herein, we introduce an atomically precise and ultrasmall cascade nanozyme based on a radical-functionalized metal-organic cage (MOC-R). This nanozyme is synthesized through the coordination of radical ligands with copper ions, resulting in a cuboctahedral structure. Results: The MOC-R exhibits

SUBMITTER: Huang C 

PROVIDER: S-EPMC11840732 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature