Neural mechanism of trigeminal nerve stimulation recovering defensive arousal responses in traumatic brain injury.

ABSTRACT: The arousal state is defined as the degree to which an individual is aware of themselves and their surroundings, and is a crucial component of consciousness. Trigeminal nerve stimulation (TNS), a non-invasive clinical neuromodulation technique, has shown potential in aiding the functional recovery of patients with impaired consciousness. Understanding the specific neuronal subpopulations and circuits through which TNS improves arousal states is essential for advancing its clinical application. Methods: A mouse model of traumatic brain injury (TBI) was established using a weight-drop technique to induce neurological dysfunction, and the arousal state was assessed through visual and auditory defensive responses. Techniques such as viral tracing, chemogenetics, patch-clamp recordings,

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC11840743 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature