Novel Scoring System for Ranking Hematopoietic Stem Cell Transplantation.

ABSTRACT:

Background

When human leukocyte antigen (HLA)-matched donors are not available for hematopoietic stem cell transplants (HSCT), there are no well-accepted guidelines for ranking 7/8 HLA-matched unrelated donors to achieve optimal transplant outcomes. A novel scoring system for ranking HLA mismatches for these donors was investigated.

Methods

High-resolution HLA types were used to determine amino acid mismatches located in the HLA antigen-recognition domain. The location and physicochemical properties of mismatched amino acids were used to assign scores for peptide binding, T-cell receptor docking, and HLA structure/function. The scores were tested using a cohort of 2319 patients with leukemia or myelodysplastic syndrome who received their first unrelated donor transplant usin

SUBMITTER: Baxter-Lowe LA 

PROVIDER: S-EPMC11840805 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature