Effect of statins on neurological functional outcomes in critically ill adult patients with traumatic brain injury: a systematic review and meta-analysis.

ABSTRACT:

Background

Statins are considered a promising therapy in traumatic brain injury (TBI) because of their role in mediating inflammatory injury and other endothelial properties. Whether they can improve patient outcomes is unknown.

Objectives

To evaluate the effect of statins in critically ill patients with TBI.

Design

Systematic review and meta-analysis of randomised controlled trials.

Eligibility criteria

Trials of adult patients with acute moderate or severe TBI.

Methods

We searched Medline, Embase, Cochrane Central and Web of Science databases for trials comparing the use of any statin with placebo or other interventions. Our primary outcome was the Glasgow Outcome Scale (GOS or GOS extended); secondary outcomes were mortality, intensive care unit (ICU)

SUBMITTER: Veillette C 

PROVIDER: S-EPMC11840907 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature