Pilot study: Initial investigation suggests differences in EMT-associated gene expression in breast tumor regions.

ABSTRACT: Triple negative breast cancer (TNBC) is the most aggressive subtype and disproportionately affects African American women. The development of breast cancer is highly associated with interactions between tumor cells and the extracellular matrix (ECM), and recent research suggests that cellular components of the ECM vary between racial groups. This pilot study aimed to evaluate gene expression in TNBC samples from patients who identified as African American and Caucasian using traditional statistical methods and emerging Machine Learning (ML) approaches. ML enables the analysis of complex datasets and the extraction of useful information from small datasets. We selected four regions of interest from tumor biopsy samples and used laser microdissection to extract tissue for gene expression cha

SUBMITTER: King KL 

PROVIDER: S-EPMC11840942 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature