Analysis of TEM micrographs with deep learning reveals APOE genotype-specific associations between HDL particle diameter and Alzheimer's dementia.

ABSTRACT: High-density lipoprotein (HDL) particle diameter distribution is informative in the diagnosis of many conditions, including Alzheimer's disease (AD). However, obtaining an accurate HDL size measurement is challenging. We demonstrated the utility of measuring the diameter of more than 1,800,000 HDL particles with the deep learning model YOLOv7 (you only look once) from micrographs of 183 HDL samples, including patients with dementia or normal cognition (controls). This method was shown to be more efficient and accurate than conventional image analysis software. Using this method, we found a higher abundance of small HDLs in participants with dementia compared to controls in patients with the apolipoprotein E (APOE) ε3ε4 genotype, whereas patients with the APOE ε3ε3 genotype had higher varia

SUBMITTER: Zheng JJ 

PROVIDER: S-EPMC11840948 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature