Association between glycation gap and impaired cardiorespiratory fitness: evidence from American adults.

ABSTRACT:

Background

Cardiorespiratory fitness (CRF) is a critical indicator of overall health, while the glycation gap (G-Gap) emerges as a potential novel biomarker for metabolic and cardiovascular risk assessment. However, the relationship between G-Gap and CRF remains incompletely understood.

Objective

To investigate the association between glycation gap and impaired CRF, and evaluate its potential as an early health risk indicator.

Methods

Using data from the National Health and Nutrition Examination Survey (NHANES, 1999-2004), we conducted a comprehensive analysis of 3,818 adult participants. G-Gap was calculated by standardizing glycated albumin (GA) and glycated hemoglobin (HbA1c) levels, comparing actual and predicted HbA1c values. Cardiorespiratory fitness was assesse

SUBMITTER: Fei M 

PROVIDER: S-EPMC11840999 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature