High-salt diet decreases FOLFOX efficacy via gut bacterial tryptophan metabolism in colorectal cancer.

ABSTRACT:

Background

FOLFOX is the recommended chemotherapy regimen for colorectal cancer (CRC), but its response rate remains low. Our previous studies have established a close relationship between gut microbiota and the anti-CRC effect of FOLFOX, though the underlying mechanisms remain unclear. Diet has been confirmed as a key factor influencing gut microbiota, and high-salt diets, representative of western dietary habits, has been shown to affect gut microbiota, immune function, and the risk of developing CRC. However, the impact of high-salt diets on the anti-CRC efficacy of FOLFOX remains unstudied. Therefore, we aimed to investigate the effect and mechanism of high-salt diets on the anti-CRC effect of FOLFOX.

Methods

We performed 16 S rRNA sequencing and T500 targeted metabolomi

SUBMITTER: Deng Y 

PROVIDER: S-EPMC11841010 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature