Associations of estimated glucose disposal rate with frailty progression: results from two prospective cohorts.

ABSTRACT:

Background

Frailty is a common geriatric syndrome associated with many adverse health outcomes. Identifying the risk factors of frailty is crucial and the insulin resistance (IR) is considered as a potential target. The estimated glucose disposal rate (eGDR) is a simple and reliable surrogate marker of IR. Associations of eGDR with frailty have not been explored. This study aimed to investigate the associations of eGDR with frailty progression.

Methods

We used data from two prospective cohorts of the China Health and Retirement Longitudinal Study (CHARLS) and Health and Retirement Study (HRS). The eGDR was calculated as follows: eGDR (mg/kg/min) = 21.158 - (0.09×waist circumference) - (3.407×hypertension) - (0.551×glycosylated hemoglobin A_1c) [waist circumference

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11841016 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature