Versatile and Controlled Synthesis of Degradable, Water-Soluble Bottlebrush Polymers with Poly(disulfide) Backbones Derived from α-Lipoic Acid.

ABSTRACT: Bottlebrush (BB) polymers, with their densely grafted side chains and unique architecture, are highly advantageous for drug delivery due to their high functional group density for drug conjugation, unimolecular nature, and enhanced biodistribution properties. These attributes enable extended blood circulation half-life, improved tumor tissue penetration, and high tumoral drug accumulation. However, the typically nondegradable, all-carbon backbones of most BB polymers limit their suitability for applications requiring controlled clearance and biodegradability. To address this, we developed degradable BB polymers with poly(disulfide) backbones synthesized via reversible addition-fragmentation chain transfer (RAFT) copolymerization of α-lipoic acid (LA), a renewable and readily available comp

SUBMITTER: Levkovsky IO 

PROVIDER: S-EPMC11841036 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature