Engineered Extracellular Vesicles from Antler Blastema Progenitor Cells: A Therapeutic Choice for Spinal Cord Injury.

ABSTRACT: Deer antler blastema progenitor cells (ABPCs) are promising for regenerative medicine due to their role in annual antler regeneration, the only case of complete organ regeneration in mammals. ABPC-derived signals show great potential for promoting regeneration in tissues with limited natural regenerative ability. Our findings demonstrate the capability of extracellular vesicles from ABPCs (EVs^ABPC) to repair spinal cord injury (SCI), a condition with low regenerative capacity. EVs^ABPC significantly enhanced the proliferation of neural stem cells (NSCs) and activated neuronal regenerative potential, resulting in a 5.2-fold increase in axonal length. Additionally, EVs^ABPC exhibited immunomodulatory effects, shifting macrophages from M1 to M2. Engineered with

SUBMITTER: Yang S 

PROVIDER: S-EPMC11841045 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature