Acute Kidney Injury, Mild Cognitive Impairment, and Dementia: A Cohort Study of Patients from SPRINT.

ABSTRACT:

Rationale & objective

It is well accepted that acute cognitive dysfunction and delirium can occur with severe acute kidney injury (AKI). Recent evidence has indicated AKI can contribute to incident dementia years later. However, these observations were limited by lack of adjudication in most of these studies and greater severity of AKI.

Study design

A retrospective cohort study.

Setting & participants

8,148 older adults at high cardiovascular risk enrolled in the Systolic Blood Pressure Intervention Trial (SPRINT).

Predictor

Adjudicated AKI as a time-varying predictor.

Outcomes

Incident mild cognitive impairment (MCI), probable dementia, and their composite.

Analytical approach

Cox proportional hazard models.

Results

Participants were 68 ± 

SUBMITTER: Nowak KL 

PROVIDER: S-EPMC11841091 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature