LD-transpeptidase-mediated cell envelope remodeling enables developmental transitions and survival in <i>Coxiella burnetii</i> and <i>Legionella pneumophila</i>.

ABSTRACT: Coxiella burnetii and Legionella pneumophila are two phylogenetically related bacterial pathogens that exhibit extreme intrinsic resistance when they enter into a dormancy-like state. This enables both pathogens to survive extended periods in growth-limited environments. Survival is dependent upon their ability to undergo developmental transitions into two phenotypically distinct variants, one specialized for intracellular replication and another for prolonged survival in the environment and host. We currently lack an understanding of the mechanisms that mediate these developmental transitions. Here, we performed peptidoglycan (PG) glycoproteome analysis and showed significant enrichment of PG structures catalyzed by LD-transpeptidases (LDTs) in the survival variants of C.

SUBMITTER: Kathayat D 

PROVIDER: S-EPMC11841132 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature