Impacts of <i>perR</i> on oxygen sensitivity, gene expression, and murine infection in <i>Clostridioides difficile</i> 630∆<i>erm</i>.

ABSTRACT: Clostridioides difficile infection (CDI), characterized by colitis and diarrhea, afflicts approximately half a million people in the USA every year, burdening both individuals and the healthcare system. C. difficile 630Δerm is an erythromycin-sensitive variant of the clinical isolate C. difficile 630 and is commonly used in the C. difficile research community due to its genetic tractability. 630Δerm possesses a point mutation in perR, an autoregulated transcriptional repressor that regulates oxidative stress resistance genes. This point mutation results in a constitutively de-repressed PerR operon in 630Δerm. To address the impacts of perR on phenotypes relevant for oxygen tolerance and relevant to a murine model of CDI, we cor

SUBMITTER: Gregory AL 

PROVIDER: S-EPMC11841134 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature