Microbial community-scale metabolic modelling predicts personalized short-chain fatty acid production profiles in the human gut.

ABSTRACT: Microbially derived short-chain fatty acids (SCFAs) in the human gut are tightly coupled to host metabolism, immune regulation and integrity of the intestinal epithelium. However, the production of SCFAs can vary widely between individuals consuming the same diet, with lower levels often associated with disease. A systems-scale mechanistic understanding of this heterogeneity is lacking. Here we use a microbial community-scale metabolic modelling (MCMM) approach to predict individual-specific SCFA production profiles to assess the impact of different dietary, prebiotic and probiotic inputs. We evaluate the quantitative accuracy of our MCMMs using in vitro and ex vivo data, plus published human cohort data. We find that MCMM SCFA predictions are significantly associated with blood-derived cl

SUBMITTER: Quinn-Bohmann N 

PROVIDER: S-EPMC11841136 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature