The causal relationships between gut microbiota and venous thromboembolism: a Mendelian randomization study.

ABSTRACT:

Background

Venous thromboembolism (VTE) is still one of the most severe health issues, increasing mortality and lengthening hospital stays. Different abundances of gut microbiota have been clinically linked to VTE and coagulopathy. However, whether gut microbiota affected VTE formation remained uncertain.

Methods

The causative links between VTE and 211 gut microbiota at phylum, class, order, family and genus level were separately investigated using two-sample Mendelian Randomization (MR) analysis. Firstly, single nucleotide polymorphisms (SNPs) locus-wide significantly (P < 1.0 × 10^- 5) related with gut microbiome abundance were extracted from large genome-wide analysis (GWAS) meta-analysis summary data. Instrumental variables (IVs) without pleiotropy were selecte

SUBMITTER: Huang P 

PROVIDER: S-EPMC11841150 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature