Resting-state degree centrality and Granger causality analysis in relation to facial working memory in patients with first-episode schizophrenia.

ABSTRACT:

Background

This study focused on the relationship between facial working memory and resting-state brain function abnormalities in patients with schizophrenia.

Methods

Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 28 first-episode schizophrenia (FSZ) patients and 33 healthy controls (HCs). Degree centrality (DC) and Granger causality analysis (GCA) were used to assess brain region connectivity. A delayed matching-to-sample task was used to examine visual working memory for faces and houses. Correlations between DC and facial working memory accuracy were analysed. Brain regions were selected as regions of interest (ROIs) and subjected to further GCA. MRI signals of the DC or GCA were extracted and analysed for correlation with clinical

SUBMITTER: Zhou S 

PROVIDER: S-EPMC11841165 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature