Initiating buprenorphine to treat opioid use disorder without prerequisite withdrawal: an updated systematic review.

ABSTRACT:

Background

Withdrawal prior to buprenorphine initiation may be intolerable or create barriers to therapy. We aim to update our previous systematic review on the efficacy and safety of buprenorphine initiation strategies that aim to omit prerequisite opioid withdrawal (POW).

Methods

We used the same search strategy for this update as in the original review with the modification of an additional term "low dose." We searched Embase and Scopus from April 11, 2020 to August 1, 2024 with searches in Google Scholar and www.

Clinicaltrials

gov . A study was included if it described patients with opioid use disorder or chronic pain that transitioned from a full mu-opioid agonist to buprenorphine without preceding withdrawal and reported withdrawal during initiation as an outco

SUBMITTER: Adams KK 

PROVIDER: S-EPMC11841166 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature