Efficacy and safety of regorafenib in the treatment of bone sarcomas: systematic review and meta-analysis.

ABSTRACT:

Background

Metastatic or recurrent bone sarcomas are often associated with an unfavorable prognosis, posing a formidable challenge in extending patients' survival. Currently, regorafenib has shown promise in treating metastatic and recurrent bone sarcomas. However, there is a lack of consensus on its efficacy and safety. This systematic review and meta-analysis aims to consolidate existing data to assess the efficacy and safety of regorafenib in bone sarcomas.

Methods

A comprehensive search strategy utilizing MeSH terms and free-text keywords was employed to systematically search the Embase, PubMed, Web of Science, and Cochrane databases up to May 26, 2024. Randomized controlled trials investigating regorafenib monotherapy for metastatic or recurrent bone sarcomas were inclu

SUBMITTER: Han Y 

PROVIDER: S-EPMC11841194 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature