Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study.

ABSTRACT: Anorexia nervosa (AN) is a severe eating disorder characterized by intense fear of weight gain, distorted body image, and extreme food restriction. This research employed advanced diffusion MRI techniques including single-shell 3-tissue constrained spherical deconvolution, anatomically constrained tractography, and spherical deconvolution informed filtering of tractograms to analyze brain network alterations in AN. Diffusion MRI data from 81 AN patients and 98 healthy controls were obtained. The structural brain connectome was constructed based on nodes set in 84 brain regions, and graph theory analysis was conducted. Results showed that AN patients exhibited significantly higher clustering coefficient and local efficiency in several brain regions, including the left fusiform gyrus, bilate

SUBMITTER: Kanzawa J 

PROVIDER: S-EPMC11841206 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature