CDCA3-MYC positive feedback loop promotes bladder cancer progression via ENO1-mediated glycolysis.

ABSTRACT:

Background

Bladder cancer (BLCA) ranks among the most prevalent malignancies of the urinary system, with its clinical diagnosis predominantly reliant on invasive procedures. Traditional chemotherapy regimens exhibit significant limitations, underscoring the urgency of identifying novel diagnostic biomarkers and strategies to enhance chemotherapy efficacy. CDCA3 has been recognized as a facilitator of BLCA progression, activated by MYBL2. However, its precise regulatory mechanisms in BLCA pathogenesis remain incompletely elucidated.

Methods

To investigate the functional role of CDCA3 in BLCA, MTT and colony formation assays were employed to assess cellular proliferation, while flow cytometry was utilized to evaluate apoptosis and intracellular ROS levels. The expression of CD

SUBMITTER: Shen D 

PROVIDER: S-EPMC11841255 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature