Profiling conserved transcription factor binding motifs in Phaseolus vulgaris through comparative genomics.

ABSTRACT: Common bean (Phaseolus vulgaris), a staple food in Latin America and Africa, serves as a vital source of energy, protein, and essential minerals for millions of people. However, genomics knowledge that breeders could leverage for improvement of this crop is scarce. We have developed and validated a comparative genomics approach to predict conserved transcription factor binding sites (TFBS) in common bean and studied gene regulatory networks. We analyzed promoter regions and identified TFBS for 12,631 bean genes with an average of 6 conserved motifs per gene. Moreover, we discovered a statistically significant relationship between the number of conserved motifs and amount of available experimental evidence of gene regulation. Notably, ERF, MYB, and bHLH transcription factor families dominat

SUBMITTER: Kondratova L 

PROVIDER: S-EPMC11841308 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature