A short ncRNA modulates gene expression and affects stress response and parasite differentiation in <i>Leishmania braziliensis</i>.

ABSTRACT: The protozoan parasite Leishmania spp. is a causative agent of leishmaniasis, a disease that affects millions of people in more than 80 countries worldwide. Apart from its medical relevance, this organism has a genetic organization that is unique among eukaryotes. Studies of the mechanisms regulating gene expression in Leishmania led us to investigate noncoding RNAs (ncRNAs) as regulatory elements. We previously identified differentially expressed (DE) ncRNAs in Leishmania braziliensis with potential roles in the parasite biology and development. Herein, we present a functional analysis of one such DE ncRNA, the 147-nucleotide-long transcript ncRNA97, which is preferentially expressed in amastigotes, the replicative form within mammalian phagocytes. By RT-qPCR the ncRN

SUBMITTER: Quilles JC 

PROVIDER: S-EPMC11841412 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature