A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma.

ABSTRACT:

Objective

Osteosarcoma is the most common primary bone cancer with a high propensity for local invasion and metastasis. An increasing number of research studies show that telomeres play an important role in the occurrence and development of cancer. Thus, we established a telomere-related signature in osteosarcoma to comprehensively evaluate the pathogenic roles of telomeres in this disease.

Methods

The data on osteosarcoma were collected from the TARGET and Gene Expression Omnibus databases. First, we constructed a telomere-related signature using univariate and LASSO Cox regression analyses. Subsequently, we analyzed the prognostic value, functional annotation, immune microenvironment, and cell communication patterns of the telomere-related signature in osteosarcoma via com

SUBMITTER: Li S 

PROVIDER: S-EPMC11841432 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature