Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer.

ABSTRACT: Inflammation and tissue damage associated with pancreatitis can precede or occur concurrently with pancreatic ductal adenocarcinoma (PDAC). We demonstrate that in PDAC coupled with pancreatitis (ptPDAC), antigen-presenting type I conventional dendritic cells (cDC1s) are specifically activated. Immune checkpoint blockade therapy (iCBT) leads to cytotoxic CD8⁺ T cell activation and elimination of ptPDAC with restoration of life span even upon PDAC rechallenge. Using PDAC antigen-loaded cDC1s as a vaccine, immunotherapy-resistant PDAC was rendered sensitive to iCBT with elimination of tumors. cDC1 vaccination coupled with iCBT identified specific CDR3 sequences in the tumor-infiltrating CD8⁺ T cells with potential therapeutic importance. This study identifies a fundament

SUBMITTER: Mahadevan KK 

PROVIDER: S-EPMC11841451 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature