Caffeic acid phenethyl ester inhibits multispecies biofilm formation and cariogenicity.

ABSTRACT:

Background

Caffeic acid phenethyl ester (CAPE), a natural phenolic compound, has demonstrated antibacterial effects. Dental caries etiology is multifactorial, including a cariogenic biofilm containing multispecies bacteria. However, the antibacterial property of CAPE on multispecies biofilm is unclear. The aim of this study was to assess the effect of CAPE on the formation and cariogenicity in biofilm containing Streptococcus mutans, Streptococcus oralis, and Streptococcus mitis.

Methods

S. mutans (ATCC 25175), S. oralis (ATCC 35037), and S. mitis (ATCC 49456T) were employed in this investigation. Each bacterial strain was cultured in the presence of CAPE, followed by susceptibility assessment through optical density measurements at

SUBMITTER: Kokilakanit P 

PROVIDER: S-EPMC11841590 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature