Reactivation of a Transplant Recipient's Inherited Human Herpesvirus 6 and Implications to the Graft.

ABSTRACT:

Background

The implications of inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) in solid organ transplantation remain uncertain. Although this trait has been linked to unfavorable clinical outcomes, an association between viral reactivation and complications has only been conclusively established in a few cases.

Methods

We used hybrid capture sequencing for in-depth analysis of the viral sequences reconstructed from sequential liver biopsies. Moreover, we investigated viral replication through in situ hybridization (U38-U94 genes), reverse transcriptase polymerase chain reaction (U89/U90 genes), immunohistochemistry, and immunofluorescence. We also performed whole transcriptome sequencing to profile the host immune response.

Results

We report a case o

SUBMITTER: Hannolainen L 

PROVIDER: S-EPMC11841639 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature