Photo-Accelerated Synthesis of Oligo(triazole amide)s.

ABSTRACT: A photo-assisted process is explored for improving the synthesis of oligo(triazole amide)s, which are prepared by solid phase synthesis using a repeated cycle of two reactions: amine-carboxylic acid coupling and copper-catalyzed azide-alkyne cycloaddition (CuAAC). The improvement of the second reaction is investigated herein. A catalytic system involving Cu(II)Cl₂, N,N,N',N″,N″-pentamethyldiethylenetriamine (PMDETA) and a titanocene photoinitiator is explored for reducing the reaction time of CuAAC. This catalyst is first tested on a model reaction involving phenylacetylene and ethyl azidoacetate in DMSO. The kinetics of these model experiments are monitored by ¹H NMR in the presence of different concentrations of the photoinitiator. It is found that 30 mol% of photoi

SUBMITTER: Petropoulos A 

PROVIDER: S-EPMC11841660 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature