A model of Notch signalling control of angiogenesis: Evidence of a role for Notch ligand heterodimerization.

ABSTRACT: The ubiquitous Notch receptor signalling network is essential for tissue growth and maintenance. Operationally, receptor activity is regulated by two principal, counterposed mechanisms: intercellular Notch transactivation triggered by interactions between receptors and ligands expressed in neighbouring cells; intracellular cis inhibition mediated by ligands binding to receptors expressed in the same cell. Moreover, different Notch receptor/ligand combinations are known to elicit distinct molecular and cellular responses, and together, these phenomena determine the strength, the duration and the specificity of Notch receptor signalling. To date, it has been assumed that these processes involve discrete ligand homomers and not heteromeric complexes composed of more than one ligand species. I

SUBMITTER: Chen D 

PROVIDER: S-EPMC11841921 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature